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Begacestat

Begacestat structure

Begacestat 

structure
  • CAS No:

    769169-27-9

  • Formula:

    C9H8ClF6NO3S2

  • Chemical Name:

    Begacestat

  • Synonyms:

    Begacestat;Begacestat(GSI-953);GSI-953;5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxyMethyl)-2-(trifluoroMethyl)propyl]-2-thiophenesulfonaMide;(2S)-S-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-hydroxy-N-Methyl-3-(trifluoroMethyl)butane-2-sulfonaMido;5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2- (trifluoromethyl)propyl] thiophene-2-sulfonamide;2-Thiophenesulfonamide, 5-chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-

Begacestat Basic Attributes

391.7381392

390.954

Characteristics

103

3.7

white to tan

1.642

355℃

169℃

DMSO: ≥15mg/mL

2-8°C

Safety Information

3

Begacestat Use and Manufacturing

Begacestat (GSI-953) is a selective β-secretase inhibitor that selectively inhibits cleavage of APP over Notch. GSI-953 is used for treating diseases such as cancer in relation to prevention of intestinal secretory metaplasia.

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