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Glutaminase C-IN-1

Glutaminase C-IN-1 structure

Glutaminase C-IN-1 

structure
  • CAS No:

    311795-38-7

  • Formula:

    C27H27BrN2O

  • Chemical Name:

    Glutaminase C-IN-1

  • Synonyms:

    5-[3-BroMo-4-(diMethylaMino)phenyl]-2,3,5,6-tetrahydro-2,2-diMethylbenzo[a]phenanthridin-4(1H)-one;Glutaminase C-IN-1;Glutaminase C-IN-1 (968);Glutaminase Inhibitor Compound 968;glutaminase inhibitor 968

Description

Glutaminase C-IN-1 (968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts.


5-[3-bromo-4-(dimethylamino)phenyl]-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one is a partially hydrogenated benzophenanthridine carrying an oxo group at C-4, geminal methyl groups at C-2 and a 3-bromo-4-(dimethylamino)phenyl group at C-5. It has a role as an EC 3.5.1.2 (glutaminase) inhibitor.

Glutaminase C-IN-1 Basic Attributes

475.42008

474.13100

-0

DTXSID90389215

Characteristics

32.3

6.2

1.39±0.1 g/cm3(Predicted)

Safety Information

NONH for all modes of transport

H413

Drug Information

5-(3-bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo(a)phenanthridin-4(1H)-one

Computed Properties

Molecular Weight:475.4
XLogP3:6.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:474.13068
Monoisotopic Mass:474.13068
Topological Polar Surface Area:32.3
Heavy Atom Count:31
Complexity:744
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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