6-BroMopyriMidine-4-carboxylic acid Methylester

Tripotassium phosphate (2eq) was added in one portion to a stirred solution of 8-chloro-6-(4, 4, 5, 5-tetramethyl- [l, 3, 2]dioxaborolan-2-yl)-chroman (leq) and methyl 4-bromopyridine-2-carboxylate (2eq) in DMF (lOvol). The mixture was degassed with nitrogen for 5 minutes, after which time Pd(dppf)2C12 (0.2eq) was added in one portion, the mixture was then heated to 60oC and stirred at this temperature for 16 hours under a nitrogen atmosphere. After this time the reaction mixture was cooled to room temperature and partitioned between ethyl acetate (5 vol) and water (5 vol). The organic layer was separated, washed sequentially with water (5vol) then brine (5vol) before being dried (MgS04), filtered andconcentrated. The resulting residue was purified using a Biotage Isolera (lOOg silica column eluting with a gradient from 0% heptane to 80% DCM / 20% heptane) to give the desired compound as a white solid

Molecular Weight:217.02
XLogP3:1.4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:215.95344
Monoisotopic Mass:215.95344
Topological Polar Surface Area:52.1
Heavy Atom Count:11
Complexity:154
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes