5-BROMO-3-METHYL-1H-PYRAZOLE
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5-BROMO-3-METHYL-1H-PYRAZOLE
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CAS No:
5744-68-3
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Formula:
C4H5BrN2
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Chemical Name:
5-BROMO-3-METHYL-1H-PYRAZOLE
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Synonyms:
3-bromo-5-methyl-1H-pyrazole;5-Bromo-3-methyl-1H-pyrazole;57097-81-1;5744-68-3;3-bromo-5-methylpyrazole;3-Bromo-5-methyl-1H pyrazole;1H-Pyrazole, 3-bromo-5-methyl-;PubChem23660;AMOT0124;AMOT0125
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CAS No:
5-BROMO-3-METHYL-1H-PYRAZOLE Use and Manufacturing
(1) Preparation of Compound IIIa: Compound IV (160g, 1mol) was added to 900ml of tetrahydrofuran, Was slowly added portionwise sodium tert-butoxide (115.2g, 1.2mol), stirred for 20 minutes, a solution of iodine benzene (243.6g, 1.2mol). The mixture was heated at reflux for 4 hours with stirring, and then stirred at room temperature overnight, TLC showed the reaction was complete, the reaction mixture was slowly poured into ice water, ethyl acetate was added, the organic phase was separated, the aqueous phase was again extracted with ethyl acetate, the organic phases combined, dried and concentrated to give compound IIIa205.3g, a yield of 87percent.Compound IV was run in acetonitrile, pyridine, With the compound iodobenzene nucleophilic substitution reaction preparation of compound III,