Bevantolol hydrochloride
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Bevantolol hydrochloride
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CAS No:
42864-78-8
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Formula:
C20H27NO4.ClH
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Chemical Name:
Bevantolol hydrochloride
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Synonyms:
2-Propanol,1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-,hydrochloride (1:1);2-Propanol,1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-,hydrochloride;1-[(3,4-Dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol hydrochloride;CI 775;Bevantolol hydrochloride;NC 1400;Ranestol;Cl 775;Vantol;Sentiloc;107751-99-5
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CAS No:
Description
Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist[1][2].
Characteristics
60
3.77710
137-138 °C
518.3°C at 760 mmHg
LD50 orl-rat: 460 mg/kg IYKEDH 26,364,1995
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)
bevantolol
Bevantolol hydrochloride Use and Manufacturing
This compound was prepared by analogy with a previously described procedure.This compound was prepared by analogy with a previously described procedure.EXAMPLE 6 The procedure of was repeated except for changing the amounts of TOEP and HVA to 1.64 g(10 mmol.) of TOEP and 9.05 g (50 mmol.) of HVA, adding 15 ml of isopropyl alcohol to TOEP and HVA, conducting the reaction for 1 hour under reflux, and using 20 ml of acetonitrile as the crystallization solvent, to obtain 2.89 g (yield:75.8%) of crude crystals of
Bevantolol is a cardioselective β-adrenergic blocker. Bevantolol is used as an antianginal, antihypertensive, antiarrhythmic.
Computed Properties
Molecular Weight:381.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:381.1706861
Monoisotopic Mass:381.1706861
Topological Polar Surface Area:60
Heavy Atom Count:26
Complexity:355
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Extract from the above information
Registered Holders
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Luzhou Kereide Pharmaceutical Co., Ltd.
Active
China
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Beijing Sihuan Kebao Pharmaceutical Co., Ltd.
Active
China
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ZHONGFU Pharmaceutical Co., Ltd.
Inactive
China
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