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Bevantolol hydrochloride

pharmaceutical raw materials
Bevantolol hydrochloride structure

Bevantolol hydrochloride 

structure
  • CAS No:

    42864-78-8

  • Formula:

    C20H27NO4.ClH

  • Chemical Name:

    Bevantolol hydrochloride

  • Synonyms:

    2-Propanol,1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-,hydrochloride (1:1);2-Propanol,1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-,hydrochloride;1-[(3,4-Dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol hydrochloride;CI 775;Bevantolol hydrochloride;NC 1400;Ranestol;Cl 775;Vantol;Sentiloc;107751-99-5

  • Categories:

    Organic Chemistry  >  Amides

Description

Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca2+ antagonist[1][2].

Bevantolol hydrochloride Basic Attributes

381.89

381.170685

DTXSID5048633

2922299090

Characteristics

60

3.77710

137-138 °C

518.3°C at 760 mmHg

LD50 orl-rat: 460 mg/kg IYKEDH 26,364,1995

Safety Information

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)

bevantolol

Bevantolol hydrochloride Use and Manufacturing

Methods of Manufacturing

This compound was prepared by analogy with a previously described procedure.This compound was prepared by analogy with a previously described procedure.EXAMPLE 6 The procedure of was repeated except for changing the amounts of TOEP and HVA to 1.64 g(10 mmol.) of TOEP and 9.05 g (50 mmol.) of HVA, adding 15 ml of isopropyl alcohol to TOEP and HVA, conducting the reaction for 1 hour under reflux, and using 20 ml of acetonitrile as the crystallization solvent, to obtain 2.89 g (yield:75.8%) of crude crystals of

Uses

Bevantolol is a cardioselective β-adrenergic blocker. Bevantolol is used as an antianginal, antihypertensive, antiarrhythmic.

Computed Properties

Molecular Weight:381.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:381.1706861
Monoisotopic Mass:381.1706861
Topological Polar Surface Area:60
Heavy Atom Count:26
Complexity:355
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • Luzhou Kereide Pharmaceutical Co., Ltd.

    China China
    Active
  • Beijing Sihuan Kebao Pharmaceutical Co., Ltd.

    China China
    Active
  • ZHONGFU Pharmaceutical Co., Ltd.

    China China
    Inactive

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