BPV(PIC)
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BPV(PIC)
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CAS No:
148556-27-8
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Formula:
C6H8K2NO9V-3
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Chemical Name:
BPV(PIC)
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Synonyms:
DIPOTASSIUM BISPEROXO(PICOLINATO)OXOVANADATE (V);BPV(PIC);Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate;Dipotassium Bisperoxovanadium(pic) dihydrate;K2 [VO(O2)2C6H4NO2]2 H2O;bpV(pic) (potassium hydrate)
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CAS No:
Safety Information
3
36/38
26
Xi
P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362
H315
BPV(PIC) Use and Manufacturing
bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 12.7 μM), and PTP-1βB (IC50 = 61 μM). bpV(pic) is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells, stimulating lipogenesis in adipocytes, and inhibiting the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes.
