8-Bromo-6-chloroimidazo[1,2-a]pyridine
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![8-Bromo-6-chloroimidazo[1,2-a]pyridine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/375891aebc3142249848d2d5009cd99a.png "8-Bromo-6-chloroimidazo[1,2-a]pyridine")
8-Bromo-6-chloroimidazo[1,2-a]pyridine
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CAS No:
957187-27-8
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Formula:
C7H4BrClN2
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Chemical Name:
8-Bromo-6-chloroimidazo[1,2-a]pyridine
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Synonyms:
8-Bromo-6-chloroimidazo[1,2-a]pyridine;MFCD12828062;SCHEMBL1983144;KS-00000RAR;DTXSID50650054;4414AF;ZINC15021379;AKOS016012572;AS-9355;6-Chloro-8-bromoimidazo[1,2-a]pyridine
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CAS No:
8-Bromo-6-chloroimidazo[1,2-a]pyridine Use and Manufacturing
A mixture of 3-bromo-5-chloropyridin-2-amine (10 g, 49 mmol) and chloroacetaldehyde (50percent in HExample 39 2'-amino-6-(6-chloroimidazo[ 1 , 2-a]pyridin-8-yl)- 1 ', 2, 2-trimethylspiro[chroman-4, 4'- imidazol]-5'(l'H)-oneStep A: 3-Bromo-5-chloro-2-pyridinamine (487 mg, 2.35 mmol) was diluted with ethanol (4 mL), followed by the addition of 2-chloroacetaldehyde (614 , 4.69 mmol). The reaction was heated at reflux for 3 hours. The reaction was cooled and loaded onto silica gel eluting with 10-50percent ethyl acetate/hexanes to yield 8-bromo-6-chloroimidazo[l, 2-a]pyridine (300 mg, 1.30 mmol, 55.2percent yield).Step B: 2'-Amino-r, 2, 2-trimethyl-6-(4, 4, 5, 5-tetramethyl
Computed Properties
Molecular Weight:231.48
XLogP3:3.1
Hydrogen Bond Acceptor Count:1
Exact Mass:229.92464
Monoisotopic Mass:229.92464
Topological Polar Surface Area:17.3
Heavy Atom Count:11
Complexity:155
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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8-Bromo-6-chloroimidazo[1,2-a]pyridine
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