4-BROMO-8-METHYLQUINOLINE

Into a 100-mL round-bottom flask, was placed 8-methylquinolin-4-ol (500 mg, 3.14 mmol, 1.00 equiv), N, N-dimethylformamide (20 mL). This was followed by the addition of tribromophosphane (851 mg, 3.14 mmol, 1.20 equiv) dropwise with stirring at room temperature. The resulting solution was stirred for 15 hours at room temperature. The reaction was then quenched by the addition of water/ice (100 mL). The pH value of the solution was adjusted to 10 with NaOH (2 mol/L). The precipitated solids were collected by filtration. This resulted in 660 mg (95percent) of 4-bromo-8-methylquinoline as a light yellow solid. MS (ES, m/z) [M+l] : 222&224.

Molecular Weight:222.08
XLogP3:3.2
Hydrogen Bond Acceptor Count:1
Exact Mass:220.98401
Monoisotopic Mass:220.98401
Topological Polar Surface Area:12.9
Heavy Atom Count:12
Complexity:160
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes