Bromoenol lactone
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Bromoenol lactone
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CAS No:
88070-98-8
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Formula:
C16H13BrO2
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Chemical Name:
Bromoenol lactone
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Synonyms:
2H-Pyran-2-one,6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-,(6E)-;2H-Pyran-2-one,6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-,(E)-;(6E)-6-(Bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one;BEL;Bromoenol lactone;Haloenol lactone;HELSS;BEL (pharmaceutical)
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CAS No:
Description
Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx[1][2].
Characteristics
26.3
4.36
1.5±0.1 g/cm3
103-106℃
467.0±45.0 °C at 760 mmHg
236.2±28.7 °C
1.716
DMSO: Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.soluble
−20°C
Safety Information
NONH for all modes of transport
3
36/37/38
26
Xi
P261-P305 + P351 + P338
H315-H319-H335
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