2-(4-BROMO-1H-PYRAZOL-1-YL)ETHANOL

The mixture of 8d (400mg, 2.72mmol), KI (671mg, 4.04mmol), KOH (290mg, 5.2mmol) and 22a (625mg, 5.0mmol) in EtOH (1OmL) were reacted under microwave condition at 155To a solution of 4-bromo-1H-pyrazole (1.00 g, 6.80 mmol) in 20 mL of DMF was successively added 2-bromoethanol (0.53 mL, 7.48 mmol), CsGeneral Procedure 77 To a stirred solution of 4-bromo-1 H-pyrazole in DMF was added sodium hydride at room temperature. The mixture was stirred for 30 minutes, [1, 3]dioxolan-2-one was added, the mixture was stirred and slowly warmed to room temperature. The reaction was monitored by TLC. After the reaction was done, EtOAc was added, washed with saturated NaHCOTo a mixture of compound 17 (600 mg, 0.242 mmol) and compound 16 (600 mg, 0.926 mmol) was added

Molecular Weight:191.03
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:189.97418
Monoisotopic Mass:189.97418
Topological Polar Surface Area:38
Heavy Atom Count:9
Complexity:91
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes