5-BROMO-2-[(4-METHOXYCARBONYL)PHENOXY]PYRIMIDINE

To a solution of methyl 4-hydroxybenzoate (260 mg, 1.71 mmol) in DMF (25 mL) at rt was added NaH (60percent, 75 mg, 1.9 mmol) and the mixture was stirred for 30 minutes. 5- Bromo-2-chloropyrimidine (300 mg, 1.55 mmol) was added and the mixture heated to 130 Examples 64-77 (Table 1) and Examples 78-83 (Table 2) show preparation of representative compounds by a procedure similar to that of Scheme 4, but with the inclusion of water (0.8percent) in the reaction mixture:

Molecular Weight:309.11
XLogP3:2.6
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:307.97965
Monoisotopic Mass:307.97965
Topological Polar Surface Area:61.3
Heavy Atom Count:18
Complexity:275
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes