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Home > Encyclopedia > 4-BROMO-4'-CHLOROBIPHENYL

4-BROMO-4'-CHLOROBIPHENYL

4-BROMO-4'-CHLOROBIPHENYL structure

4-BROMO-4'-CHLOROBIPHENYL 

structure
  • CAS No:

    23055-77-8

  • Formula:

    C12H8BrCl

  • Chemical Name:

    4-BROMO-4'-CHLOROBIPHENYL

  • Synonyms:

    4-BROMO-4"-CHLOROBIPHENYL;4-bromo-4"-chloro-1,1"-biphenyl;4"-chloro-4-bromo-biphenyl;1-bromo-4-(4-chlorophenyl)benzene;1,1"-Biphenyl, 4-bromo-4"-chloro-;1-(4-BROMOPHENYL)-4-CHLOROBENZENE;4-Chloro-4"-bromobiphenyl;AMTDA139;AMBZ0330;SCHEMBL3869855

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

4-BROMO-4'-CHLOROBIPHENYL Basic Attributes

267.54892

265.95

Characteristics

0

5.7

1.463±0.06 g/cm3(Predicted)

147 °C

Safety Information

P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, P501

H302

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

4-BROMO-4'-CHLOROBIPHENYL Use and Manufacturing

A solution of 4-chlorobiphenyl (3.0 g, 15.9 mmol) in acetic acid (50 mL) was carefully treated with bromine (1.1 mL, 20.7 mmol) at room temperature. The reaction mixture was heated to reflux for 4 h, cooled to room temperature and treated with excess propene until the mixture became clear. The solution was concentrated to a thick slurry, diluted with CH2Cl2 (50 mL) and washed successively with water and 2N NaOH. The organic extract was dried over MgSO4, filtered and concentrated. Purification by re-crystallization form EtOAc gave the aryl bromide (3.57g, 84percent) as a white crystalline solid. 1H NMR (CDCl3) δ 7.57 (m, 2H), 7.48 (m, 2H), 7.41 (m, 4H).

Computed Properties

Molecular Weight:267.55
XLogP3:5.7
Rotatable Bond Count:1
Exact Mass:265.94979
Monoisotopic Mass:265.94979
Heavy Atom Count:14
Complexity:167
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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