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CA-074

CA-074 structure

CAS No:
134448-10-5
Formula:
C18H29N3O6
Chemical Name:
CA-074
Synonyms:
INHIBITOR FOR CATHEPSIN B;CATHEPSIN B INHIBITOR III;CA-074;[L-3-TRANS-(PROPYLCARBAMOYL)OXIRANE-2-CARBONYL]-L-ISOLEUCYL-L-PROLINE;(L-3-TRANS-(PROPYLCARBAMYL)OXIRANE-2-CARBONYL)-L-ISOLEUCYL-L-PROLINE;[L-3-TRANS-(PROPYLCARBOMOYL)OXIRANE-2-CARBONYL]-L-ISOLEUCYL-L-PROLINE;L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE;L-TRANS-EPOXYSUCCINYL (PROPYLAMIDE)-ILE-PRO-OH

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Description

CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.

CA-074 Basic Attributes

Molecular Weight：

383.44

Exact Mass：

383.20600

Characteristics

PSA：

128.34000

XLogP3：

0.60620

Appearance：

solid

Density：

1.267±0.06 g/cm3(Predicted)

Boiling Point：

728.9±60.0 °C(Predicted)

Flash Point：

394.7ºC

Refractive Index：

1.539

Water Solubility：

Soluble in methanol at 1mg/ml. Also soluble in DMSO or ethanol.

Storage Conditions：

−20°C

Vapor Pressure：

0mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH：

Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES. (See all compounds classified as Cysteine Proteinase Inhibitors.)|Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)

MeSH Entry Terms：

1-((S)-3-methyl-2-(((2S,3S)-3-propylcarbamoyl-oxiranecarbonyl)-amino)-pentanoyl)-pyrrolidine-2-carboxylic acid

Computed Properties

Molecular Weight:383.4
XLogP3:0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:383.20563565
Monoisotopic Mass:383.20563565
Topological Polar Surface Area:128
Heavy Atom Count:27
Complexity:596
Defined Atom Stereocenter Count:4
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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CA-074

CAS No.: 134448-10-5

Content: 99.00%

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Creative Enzymes Contact Supplier

US
6 YRS

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Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

Cathepsin B Inhibitor III

CAS No.: 134448-10-5

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CA-074 ME

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Guide of CA-074

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Recommended Suppliers
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CA-074

SDS

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