 Home > Encyclopedia > C75

C75

C75 structure

CAS No:
191282-48-1
Formula:
C14H22O4
Chemical Name:
C75
Synonyms:
TETRAHYDRO-4-METHYLENE-2-OCTYL-5-OXO-3-FURANCARBOXYLIC ACID;C75;(2S,3R)-4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid;(2R,3S)-4-METHYLIDENE-5-OXO-2-N-OCTYL-OXOLANE-3-CARBOXYLIC ACID;(2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylicacid;(2R,3S)-rel-Tetrahydro-4-Methylene-2-octyl-5-oxo-3-furancarboxylic Acid;trans-Tetrahydro-4-Methylene-2-octyl-5-oxo-3-furancarboxylic Acid;trans-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
Categories:
Organic Chemistry > Lactones

Description

C75 trans is an enantiomer of C75. C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM.

3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-, (2R,3S)-rel- is a gamma-lactone.

ChEBI: (2R,3S)-C75 is a 4-methylidene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid that has 2R,3S-configuration. It is an enantiomer of a (2S,3R)-C75.

C75 Basic Attributes

Molecular Weight：

254.32

Exact Mass：

254.151810

Color/Form：

off-white

HScode：

2932190090

Characteristics

PSA：

63.6

XLogP3：

3.65

Appearance：

off-white solid

Density：

1.08±0.1 g/cm3(Predicted)

Boiling Point：

432.1±45.0 °C(Predicted)

Flash Point：

159.2±22.2 °C

Refractive Index：

1.489

Water Solubility：

DMSO: 18 mg/mL

Storage Conditions：

2-8°C

Vapor Pressure：

0mmHg at 25°C

PKA：

3.08±0.40(Predicted)

Critical Temperature & Pressure：

2-8°C

Safety Information

wgk germany：

Storage features：

Store at +4°C

Drug Information

MeSH Entry Terms：

4-methylene-2-octyl-5-oxofuran-3-carboxylic acid

C75 Use and Manufacturing

trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a well-known fatty acid synthase (FAS) inhibitor. Studies show that trans-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic Acid is a cell cycle arrest inducer in hepatocellular carcinoma (HCC) cell lines. It has also been shown to blocks resistin-induced increases in lipid accumulation by human macrophages.

Computed Properties

Molecular Weight:254.32
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:254.15180918
Monoisotopic Mass:254.15180918
Topological Polar Surface Area:63.6
Heavy Atom Count:18
Complexity:322
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of C75

Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

FAS Inhibitor, C75

CAS No.: 191282-48-1

Content: 98%

Inquiry