2-Bromo-4-iodobenzoic acid

(1 g, 3.06 mmol) was added to an eggplant-shaped flask, and dried dichloromethane was added.Thionyl chloride (433 mg, 3.67 mmol) and N, N-dimethylformamide (catalytic amount) were added dropwise. Heat to reflux and stir for 3 hours. After completion of the reaction, the mixture was cooled to room temperature, and the reaction solution was slowly poured into iced aqueous ammonia and stirred at room temperature for 2 hours. The aqueous phase was extracted three times with dichloromethane, and the organic phase was combined, dried over anhydrous sodium sulfate, concentration on a rotary evaporator and purification on a silica gel column gave 400 mg of the title compound. (1 g, 3.06 mmol) was added to an eggplant-shaped flask, and dried dichloromethane was added. Thionyl chloride (433 mg, 3.67 mmol) and N, N-dimethylformamide (catalyticamount) were added dropwise. Heat to reflux and stir for 2 hours. After completion of the reaction, the mixture was cooled to room temperature, and dimethylamine (3.1 ml, 6.06 mmol) was added dropwise. After thecompletion of the reaction, the aqueous phase was extracted with EtOAcconcentrate on a rotary evaporator and purify on a silica gel column to obtain the target compound 550mg

Molecular Weight:326.91
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:325.84394
Monoisotopic Mass:325.84394
Topological Polar Surface Area:37.3
Heavy Atom Count:11
Complexity:163
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes