2-Bromo-4-phenylpyridine
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2-Bromo-4-phenylpyridine
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CAS No:
54151-74-5
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Formula:
C11H8BrN
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Chemical Name:
2-Bromo-4-phenylpyridine
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Synonyms:
Pyridine,2-bromo-4-phenyl-;2-Bromo-4-phenylpyridine;4-Phenyl-2-bromopyridine
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CAS No:
Characteristics
12.9
3.5
1.4±0.1 g/cm3
65-66 °C @ Solvent: Ligroine
311.7°C at 760 mmHg
142.3±22.3 °C
1.606
2-Bromo-4-phenylpyridine Use and Manufacturing
Dimethylaminoethanol (DMAE, 1.50 mL, 15.0 mmol) was dissolved in hexane (20.0 mL) stirred at ice-cooling. A small amount of n-butyllithium (2.5 mol / L hexane solution, 12.0 mL, 30.0 mmol) was successively dropped under ice-cooling, and the mixture was stirred for 30 minutes. A small amount of 4-phenylpyridine (776 mg, 5.00 mmol) in hexane (30.0 mL) was added dropwise under ice-cooling, and the mixture was stirred for 1 hour in this state.After the reaction solution was cooled to -78 ° C, a small amount of the solution (15.0 mL) of carbon tetrafromide (6.30 g, 18.0 mmol) was successively dropped, and the mixture was stirred for 50 minutes. The purified water was added under ice cooling to stop the reaction, followed by extraction with ethyl acetate (100 mL × 2). The organic layer was washed with saturated brine, then dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography using ethyl acetate / hexane (1/4 (volume ratio)) as an elution solvent to obtain Compound 7 in a yield of 645 mg (yield 55.1percent).General procedure: 2, 4-dibromopyridine (0.12 g, 0.50 mmol), phenylboronic acid pinacol ester (0.11 g, 0.55 mmol), KOH (56 mg, 1.0 mmol), Pd(OAc)General procedure: 2, 5-dibromopyridine (0.12 g, 0.50 mmol), phenylboronic acid (67 mg, 0.55 mmol), K
Pyridine, 2-bromo-4-phenyl-: INACTIVE
Computed Properties
Molecular Weight:234.09
XLogP3:3.5
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:232.98401
Monoisotopic Mass:232.98401
Topological Polar Surface Area:12.9
Heavy Atom Count:13
Complexity:154
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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