 Home > Encyclopedia > 2-Bromo-4-phenylpyridine

2-Bromo-4-phenylpyridine

2-Bromo-4-phenylpyridine structure

CAS No:
54151-74-5
Formula:
C11H8BrN
Chemical Name:
2-Bromo-4-phenylpyridine
Synonyms:
Pyridine,2-bromo-4-phenyl-;2-Bromo-4-phenylpyridine;4-Phenyl-2-bromopyridine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Request for Quotation

2-Bromo-4-phenylpyridine Basic Attributes

Molecular Weight：

234.09

Exact Mass：

234.09

DSSTox ID：

DTXSID8068915

HScode：

2933399090

Characteristics

PSA：

12.9

XLogP3：

3.5

Density：

1.4±0.1 g/cm3

Melting Point：

65-66 °C @ Solvent: Ligroine

Boiling Point：

311.7°C at 760 mmHg

Flash Point：

142.3±22.3 °C

Refractive Index：

1.606

2-Bromo-4-phenylpyridine Use and Manufacturing

Methods of Manufacturing

Dimethylaminoethanol (DMAE, 1.50 mL, 15.0 mmol) was dissolved in hexane (20.0 mL) stirred at ice-cooling. A small amount of n-butyllithium (2.5 mol / L hexane solution, 12.0 mL, 30.0 mmol) was successively dropped under ice-cooling, and the mixture was stirred for 30 minutes. A small amount of 4-phenylpyridine (776 mg, 5.00 mmol) in hexane (30.0 mL) was added dropwise under ice-cooling, and the mixture was stirred for 1 hour in this state.After the reaction solution was cooled to -78 ° C, a small amount of the solution (15.0 mL) of carbon tetrafromide (6.30 g, 18.0 mmol) was successively dropped, and the mixture was stirred for 50 minutes. The purified water was added under ice cooling to stop the reaction, followed by extraction with ethyl acetate (100 mL × 2). The organic layer was washed with saturated brine, then dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography using ethyl acetate / hexane (1/4 (volume ratio)) as an elution solvent to obtain Compound 7 in a yield of 645 mg (yield 55.1percent).General procedure: 2, 4-dibromopyridine (0.12 g, 0.50 mmol), phenylboronic acid pinacol ester (0.11 g, 0.55 mmol), KOH (56 mg, 1.0 mmol), Pd(OAc)General procedure: 2, 5-dibromopyridine (0.12 g, 0.50 mmol), phenylboronic acid (67 mg, 0.55 mmol), K

Manufacturing Info：

Pyridine, 2-bromo-4-phenyl-: INACTIVE

Computed Properties

Molecular Weight:234.09
XLogP3:3.5
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:232.98401
Monoisotopic Mass:232.98401
Topological Polar Surface Area:12.9
Heavy Atom Count:13
Complexity:154
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-Bromo-4-phenylpyridine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

2-Bromo-4-phenylpyridine

CAS No.: 54151-74-5

Content: 99.00%

Inquiry
Jinshu Peptide Co.,Ltd Contact Supplier

CN
3 YRS

Business licensed

Distributor Supplier

Factory direct sale 2-BROMO-4-PHENYLPYRIDINE human with Safe Delivery

CAS No.: 54151-74-5

Grade: Industrial Grade

Content: 99%

Inquiry