1-(4-Bromophenyl)pyrrolidine

Step 82a: l-(4-Bromophenyl)pyrrolidine (Compound 0601-155)A mixture of 4-bromoaniline (1 g, 5.81 mmol), CsStep 82a: 1-(4-Bromophenyl)pyrrolidine (Compound 0601-155)[0550]A mixture of 4-bromoaniline (1 g, 5.81 mmol), CsDMF (20mL) in, 4-bromo-aniline (1g, 5.81mmol), Cs2CO3 (5.68g, 17.44mmol), 1, 4- dibromobutane (1.88g, 8.72mmol) was stirred overnight in a mixture of 60 of, after cooling to room temperature, the mixture was diluted with water (200mL), and extracted with ethyl acetate (2x100mL). The organic layer was washed with water (3 × 100 mL) and brine (100 mL), dried over Na2SO4, and purified by column chromatography on silica gel (petroleum ether) and concentrated to give the compound 0601-155 as a colorless oil It was (720mg, 46percent).Reference Example 5

Molecular Weight:226.11
XLogP3:4.3
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:225.01531
Monoisotopic Mass:225.01531
Topological Polar Surface Area:3.2
Heavy Atom Count:12
Complexity:135
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes