1-Bromo-3-chloro-5-methoxybenzene
-
1-Bromo-3-chloro-5-methoxybenzene
structure -
-
CAS No:
174913-12-3
-
Formula:
C7H6BrClO
-
Chemical Name:
1-Bromo-3-chloro-5-methoxybenzene
-
Synonyms:
Benzene,1-bromo-3-chloro-5-methoxy-;1-Bromo-3-chloro-5-methoxybenzene;3-Bromo-5-chloroanisole
- Categories:
-
CAS No:
Characteristics
9.2
3.9
1.564±0.06 g/cm3(Predicted)
236.5±20.0 °C(Predicted)
96.8±21.8 °C
1.556
Room temperature.
1-Bromo-3-chloro-5-methoxybenzene Use and Manufacturing
steps 1 and 2-A solution of 1-bromo-3-chloro-5-fluoro-benzene (42a, 55 g, 263 mmol) was cooled to 0° C. and treated with a 25percent methanolic sodium methoxide solution (68 mL, 315 mmol) and heated to 40° C. for 3 h. The solution was cooled and partitioned between water (1 L) and a 1:1 mixture of hexane/diethyl ether (3.x.200 mL). The combined extracts were washed with brine (60 mL), dried (NaStep 1 : 1-Bromo-3-chloro-5-methoxybenzene. 1 -Bromo-3-chloro-5-fluorobenzene (1 g, 4.77 mmol, 1 equiv.) was treated at 0 °C with sodium methoxide (25 percent in MeOH, 1.2 ml_, 5.71 mmol, 1.2 equiv.). The reaction mixture was stirred at 100 °C for 3 h. The solution was concentrated under reduced pressure, the crude product was extracted with DCM, washed with H-(Steps 1-5 are depicted in Scheme 9) A 100 ml round bottom flask was charged under a stream of nitrogen with 3, 5-dichlorobenzonitrile (81a, 7.0 g, 40.69 mmol) and anhydrous DMF (75 mL). To the solution was added sodium methoxide (2.26 g, 44.76 mmol) and resulting solution was stirred further at RT for 24 h. When the reaction was complete, aqueous 10percent hydrochloric acid added drop wise to the reaction vessel. The crude mixture was extracted with EtOAc and sequentially washed with aqueous acid, water and brine. The EtOAc extracts were dried (Na
Computed Properties
Molecular Weight:221.48
XLogP3:3.9
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:219.92906
Monoisotopic Mass:219.92906
Topological Polar Surface Area:9.2
Heavy Atom Count:10
Complexity:110
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 1-Bromo-3-chloro-5-methoxybenzene
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
3 YRS
Business licensedTrader Supplier of peptoneInquiryCAS No.: 174913-12-3Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamineInquiryCAS No.: 174913-12-3Grade: Industrial GradeContent: 99%
Learn More Other Chemicals
-
BENZYL GLYCIDYL ETHER
2930-05-4
-
Benzonitrile, 4-ethenyl-2-fluoro- (9CI)
433939-83-4
-
Isooctyl acrylate
29590-42-9
-
Biphenyl-4-O-sulfamate Formula
4371-23-7
-
1-AMINO-2-TERT-BUTYLCYCLOHEXANECARBOXYLIC ACID Formula
412924-89-1
-
1-[3-(CHLOROMETHYL)-2,4,6-TRIMETHYLPHENYL]ETHANONE Formula
412013-51-5
-
2-Bromo-2-methylpentane Structure
4283-80-1
-
Ethyl 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate Structure
474709-76-7
-
What is 1-Methoxy-2-propanol
107-98-2
-
What is Methyl vinyl ether-monoethyl maleate copolymer
25087-06-3
1-Bromo-3-chloro-5-methoxybenzene
SDSRequest for Quotation