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2-Bromo-6-methylpyrazine

2-Bromo-6-methylpyrazine structure

CAS No:
914452-71-4
Formula:
C5H5BrN2
Chemical Name:
2-Bromo-6-methylpyrazine
Synonyms:
Pyrazine,2-bromo-6-methyl-;2-Bromo-6-methylpyrazine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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2-Bromo-6-methylpyrazine Basic Attributes

Molecular Weight：

173.0106

Exact Mass：

173.01

HScode：

2933990090

Characteristics

PSA：

25.8

Density：

1.6±0.1 g/cm3

Boiling Point：

196℃

Flash Point：

72℃

Refractive Index：

1.558

2-Bromo-6-methylpyrazine Use and Manufacturing

General procedure: To a stirred solution of 1 (100mg, 577.99mumol), 2 (168mg, 924.79mumol) in DMF:water (5mL, 1:1), it was added Na2CO3 (141 mg, 1.33 mmol) and 1 mg of PdNP at room temperature. The resulting reaction mixture was heated at 100 C for 15 min, after completion of reaction reaction mass was cooled to room temperature, diluted with H2O (10 mL) and extracted with EtOAc (3x15 mL). The combined organic layer was washed with brine solution, dried over Na2SO4, filtered and concentrated under reduced pressure to afford crude compound, which was triturated with pet ether to delivered 3 (120 mg, 90%) as off-white solid. 1H NMR (500 MHz, CDCl3) delta: 8.79 (d, J = 5.0 Hz, 1H), 8.34 (d, J = 5.0 Hz, 1H), 7.70 - 7.51 (m, 1H), 7.04 - 6.92 (m, 1H), 4.09 - 3.89 (m, 2H), 2.66 - 2.59 (m, 1H); 13C NMR (126 MHz, CDCl3) delta 153.01, 151.40, 150.56, 149.51, 141.92, 138.57, 129.50, 119.66, 111.23, 109.83, 56.02, 56.01, 21.76; LC-MS (ESI): 231.16 (M+H).To a solution of To the stirred solution of

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