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5-Bromo-8-quinolinamine

5-Bromo-8-quinolinamine structure

CAS No:
53472-18-7
Formula:
C9H7BrN2
Chemical Name:
5-Bromo-8-quinolinamine
Synonyms:
8-Quinolinamine,5-bromo-;5-Bromo-8-quinolinamine;8-Amino-5-bromoquinoline
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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5-Bromo-8-quinolinamine Basic Attributes

Molecular Weight：

223.07

Exact Mass：

223.07

DSSTox ID：

DTXSID60346658

HScode：

2933499090

Characteristics

PSA：

38.9

XLogP3：

2.6

Density：

1.6±0.1 g/cm3

Melting Point：

109-110 °C

Boiling Point：

353.3°C at 760 mmHg

Flash Point：

167.5±23.7 °C

Refractive Index：

1.732

Safety Information

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501

Hazard Statements：

H302

5-Bromo-8-quinolinamine Use and Manufacturing

4.1.16 Quinolin-8-amine (0.20 g, 1.38 μMol) was dissolved in acetonitrile (20 mL), and N-bromosuccinimide (0.26 g, 1.43 μMol) was added to the solution. The mixture was stirred at room temperature for 30 minutes. Water was addedto the mixture. The organic layer was extracted with ethyl acetate, dried over anhydrous sodium sulfate, and concentratedunder reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate = 90/10-> 70/30) to obtain compound 117-1 (0.15 g, 50percent).1H NMR (300 MHz, DMSO-d6, δ): 8.76 (d, J = 3.3 Hz, 1H), 8.42 (d, J = 8.1 Hz, 1H), 7.56 (d, J = 8.4 Hz, 1H), 7.48 (dd, J = 8.4, 4.2 Hz, 1H), 6.80 (d, J = 8.1 Hz, 1H), 5.04 (br, 2H).To a solution of 8-aminoquinoline (1 g, 4.8 mmol) in CH3CN (30 mL) were added NBS (1.28 g, 7.2 mmol). The reaction mixture was stirred at RT for 2 hour. The residue was treated with water and extracted with EA. The extracts were concentrated and the residue purifiled by silica gel chromatography to afford 5-bromo-8-quinolylamine (760 mg).Add 1 magnetic stirrer, In a 500 ml three-necked flask, 10 g (34.8 mmol) of intermediate D and 9.6 g (38.28 mmol) of

Computed Properties

Molecular Weight:223.07
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:221.97926
Monoisotopic Mass:221.97926
Topological Polar Surface Area:38.9
Heavy Atom Count:12
Complexity:163
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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5-BROMO-QUINOLIN-8-YLAMINE

CAS No.: 53472-18-7

Content: 99.00%

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Wuhan Pnq Int Trade Co., Ltd Contact Supplier

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CAS No.: 53472-18-7

Grade: Pharmaceutical grad

Content: 99%

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