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3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE

3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE structure

CAS No:
102830-75-1
Formula:
C6H5BrClNO
Chemical Name:
3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE
Synonyms:
3-Bromo-5-chloro-2-methoxypyridine;2-Methoxy-3-Bromo-5-Chloropyridine;3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE;PYRIDINE, 3-BROMO-5-CHLORO-2-METHOXY-;MFCD08059322;PubChem6584;SCHEMBL3634770;CTK4A1525;DTXSID70544002;ABBYPHARMA AP-11-5380
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE Basic Attributes

Molecular Weight：

222.47

Exact Mass：

220.924301

DSSTox ID：

DTXSID70544002

HScode：

2933399090

Characteristics

PSA：

22.1

XLogP3：

2.5

Density：

1.650±0.06 g/cm3(Predicted)

Melting Point：

49.0 to 53.0 °C

Boiling Point：

215.8±35.0 °C(Predicted)

Flash Point：

84.3±25.9 °C

Refractive Index：

1.560

Vapor Pressure：

0.212mmHg at 25°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

UN 2811 6.1 / PGIII

hazard class code：

safety instructions：

Marks：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE Use and Manufacturing

PREPARATION 13; (5-Chloro-2-methoxypyridin-3-yl)boronic acid a) 3-Bromo-5-chloro-2-methoxypyridineA solution of bromine (1.5 mL, 29.28 mmol) in glacial acetic acid (7 mL) was slowly added to a mixture of 5-chloro-2-methoxypyridine (2.1 g, 14.63 mmol) and sodium acetate (1.2 g, 14.63 mmol) in glacial acetic acid (7 mL) and the resulting mixture was stirred at 80 °C for 6 hours. The reaction was allowed to cool down to ambient temperature and then diethyl ether and water were added. The organic layer was separated, washed with a 1N aqueous solution of sodium hydroxide and a 4percent aqueous solution of sodium bisulphite, dried over magnesium sulphate and the solvent removed under reduced pressure. The residue was purified by flash chromatography (100percent hexanes) to give the title compound (2.1 g, 64percent) as a white solid.PREPARATION 13; (5-Chloro-2-methoxypyridin-3-yl)boronic acid a) 3-Bromo-5-chloro-2-methoxypyridine A solution of bromine (1.5 mL, 29.28 mmol) in glacial acetic acid (7 mL) was slowly added to a mixture of 5-chloro-2-methoxypyridine (2.1 g, 14.63 mmol) and sodium acetate (1.2 g, 14.63 mmol) in glacial acetic acid (7 mL) and the resulting mixture was stirred at 80 C for 6 hours. The reaction was allowed to cool down to room temperature and then diethyl ether and water were added. The organic layer was separated, washed with a 1 N aqueous solution of sodium hydroxide and a 4percent aqueous solution of sodium bisulphite, dried over magnesium sulphate and the solvent removed under reduced pressure. The residue was purified by flash chromatography (100percent hexanes) to give the title compound (2.1 g, 64percent) as a white solid. To a mixture of To a mixture of To a stirred solution of

Computed Properties

Molecular Weight:222.47
XLogP3:2.5
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:220.92430
Monoisotopic Mass:220.92430
Topological Polar Surface Area:22.1
Heavy Atom Count:10
Complexity:114
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

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3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE 99%

CAS No.: 102830-75-1

Content: 99%

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shanghai jinghui industrial co.ltd Contact Supplier

CN
4 YRS

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Trader Supplier of Fluorine containing fine chemicals Pharmaceutical

3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE 99% colorless liquid JINGHUI

CAS No.: 102830-75-1

Content: 99%

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Guide of 3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE

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