4-bromo-2-iodo-6-nitroaniline

4-Bromo-2-iodo-6-nitroaniline.4-Bromo-2-nitroaniline (14.3g, 0.0659 mol) was added in one portion to iodine (17.6g, 0.0692 mol) dissolved in ethanol (30OmI)4-bromo-2-nitroaniline (1.4 g, 6.45 mmol) was added to iodine (1.801 g, 7.10 mmol) in EtOH (30 mL), followed by silver sulfate (2.213 g, 7.10 mmol). The reaction mixture was stirred at room temperature overnight and filtered. The solid was washed with EtOAc. The filtrate was concentrated. The crude product was dissolved in a small amount of chloroform and charged to a 120 g silica gel cartridge which was eluted with 5percent for 3 min., then an 18 min gradient from 5percent to 40percent. The desired fractions were combined and concentrated to give Intermediate 1A (1.8 g, 5.25 mmol, 81percent yield) as a brown solid. H1 NMR (500 MHz, methanol-d4) δ 8.25(d, J=2.2 Hz, 1H), 8, 04(d, J=2.2 Hz, 1H); LC-MS: method A, RT=2.08 min; No MS (ESI) was observed;

Molecular Weight:342.92
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:341.85009
Monoisotopic Mass:341.85009
Topological Polar Surface Area:71.8
Heavy Atom Count:12
Complexity:187
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes