8-Bromo-3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione

259.06

259.06

233-846-6

FZG87K1MQ6

164940

DTXSID7044768

29395900

69.3

0.08

White crystalline powder

1.862±0.06 g/cm3(Predicted)

307-309 °C @ Solvent: 1,4-Dioxane

Decomposes at 300 ºC

237.7±31.5 °C

1.652

H2O: soluble

-20°C Freezer

5.49E-09mmHg at 25°C

5.45None

III

6.1(b)

2811

20/21/22

24/25-36/37

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

In overdose, bromotheophylline does not produce hepatic toxicity.

This pharmacokinetic property has not been determined.

Bromotheophylline is used as a diuretic and also, in combination with [DB00316], it is used for the relief of temporary water weight gain, bloating, swelling and full feeling associated with the premenstrual and menstrual periods.

Bromotheophylline diuretic action will produce an immediate increase in urination frequency. This effect aids in the relief of bloating and menstrual pain. This diuretic function is performed by the an increase in glomerular filtration and a potential effect in the tubular reabsorption as it is established that the administration of these agents produce a rise in the urinary concentration of sodium a chloride and thus, an increase in their rates of excretion.

When administered after one single oral dosage, bromotheophylline is rapidly absorbed and it reaches a maximal plasma concentration of 2.5 mg/L in 0.78 hours. The mean residence time is registered to be of 12 hours with an AUC in the first 8 hours of 27 mg.h/L.|This pharmacokinetic property has not been determined.

This pharmacokinetic property has not been determined.

The apparent elimination half-life is registered to be 21.35 hours.

Bromotheophylline is part of the group of the xanthines. As part of this group, it is thought that bromotheophylline increases the permeability of the renal tubule, increases glomerular filtration rate and inhibits the sodium reabsorption in the proximal tubule. It is thought but not confirmed that pamabrom as a mixture seems to have an additional mechanism of action in which the presence of 2-amino-2-methyl-1-propanol produces the suppression of the antidiuretic hormone in the posterior pituitary gland.

1H-Purine-2,6-dione, 8-bromo-3,9-dihydro-1,3-dimethyl-: INACTIVE