1-Bromo-2,3-dimethyl-4-fluoroBenzene

400g of methylene chloride, 124g of 2, 3-dimethylfluorobenzene, and 5g of aluminum trichloride are added sequentially to a 1L three-necked reaction flask and stirred at 20°C; 16-32 g of bromine was released from a constant pressure dropping funnel containing 160 g of bromine and added to a three-neck reaction flask, then stirred at 30° C to initiate a reaction and produce a large amount of hydrogen bromide to make the reaction solution red. At this point, the remaining bromine in the constant-pressure dropping funnel was further added dropwise to the three-neck reaction flask, stirred at 20° C, after the addition was completed, the reaction was completed for 0.5 hours. After the reaction was completed, the reaction solution subjected to Post-treatment: 50 ml of saturated aqueous sodium sulfite solution was added dropwise to the three-necked reaction solution, remove a small amount of unreacted bromine. At room temperature, the reaction solution gradually became colorless, indicating that the bromine treatment was complete. The three-necked reaction flask liquid was allowed to stand, and the layers were separated into an aqueous phase and an organic phase, and aqueous phase was additionally retained. The organic phase was dried over anhydrous sodium sulfate and then filtered to obtain a filtrate and a cake and filter cake was washed with a little methylene chloride. The resulting liquid phase was combined with the filtrate to obtain an organic phase. The organic phase was concentrated under reduced pressure at 50-55°C to essentially free of liquid, and product 189g was obtained. The hydrogen bromide gas generated during the reaction was led through a pipe connected to a three-necked reaction flask and led to an exhaust gas absorption treatment system where it was absorbed by an aqueous solution of sodium hydroxide. The GC spectrum is shown in Fig. 2. In Fig. 2, 6.8 min was 2, 3-dimethylfluorobenzene raw material , 3.8 min was 3-bromo-6-fluoro-o-xylene, and 8.9min is the reaction product of ortho-substituted by-products, The data calculation results show: The purity of the product was 88.4percent, the by-reaction product was very small (about 3.3percent), and the remainder was mainly raw, and the calculated yield was 87percent.

Molecular Weight:203.05
XLogP3:3.4
Hydrogen Bond Acceptor Count:1
Exact Mass:201.97934
Monoisotopic Mass:201.97934
Heavy Atom Count:10
Complexity:116
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes