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Carboxyfluorescein

Carboxyfluorescein structure

CAS No:
72088-94-9
Formula:
C21H12O7
Chemical Name:
Carboxyfluorescein
Synonyms:
Spiro[isobenzofuran-1(3H),9′-[9H]xanthene]-ar-carboxylic acid,3′,6′-dihydroxy-3-oxo-;3′,6′-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthene]-ar-carboxylic acid;Fluoresceincarboxylic acid;Carboxyfluorescein;5(6)-Carboxyfluorescein;C 194;80537-70-8;94595-55-8
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

5(6)-Carboxyfluorescein contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid; cell-impermeant 5,6-FAM can also be used as a nonfixable polar tracer to investigate fusion, lysis and gap-junctional communication and to detect changes in cell or liposome volume.

5(6)-carboxyfluorescein is a commercially available mixture of 5-carboxyfluorescein and 6-carboxyfluorescein isomers. A fluorescent dye, it is commonly used as a tracer agent. It has a role as a tracer and a fluorescent dye. It contains a 5-carboxyfluorescein and a 6-carboxyfluorescein.

Carboxyfluorescein Basic Attributes

Molecular Weight：

752.63

Exact Mass：

752.117

EC Number：

276-331-1

HScode：

29335995

Characteristics

PSA：

227

Density：

1.3418 (rough estimate)

Melting Point：

275 °C

Water Solubility：

H2O: slightly soluble

Storage Conditions：

Storeat2-8

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36-36/37/38-20/21/22

safety instructions：

37/39-26-36-22

RTECS Number：

CQ7700000

Marks：

Xi,Xn

Precautionary statement(s)：

P261, P264, P272, P280, P302+P352, P305+P351+P338, P321, P333+P313, P337+P313, P363, P501

Hazard Statements：

H317

GHS Classification：

|Warning|H317 (33.33%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P264, P272, P280, P302+P352, P305+P351+P338, P321, P333+P313, P337+P313, P363, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)

MeSH Entry Terms：

5(6)-carboxyfluorescein

Carboxyfluorescein Use and Manufacturing

Uses

A useful reagent for the preparation of hydrolytically stable fluorescent conjugates and is a useful starting material for the synthesis of other fluorescein-derives reagent

Manufacturing Info：

Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-ar-carboxylic acid, 3',6'-dihydroxy-3-oxo-: ACTIVE

Computed Properties

Molecular Weight:752.6
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:2
Exact Mass:752.11660544
Monoisotopic Mass:752.11660544
Topological Polar Surface Area:227
Heavy Atom Count:56
Complexity:1270
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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