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Home > Encyclopedia > Chlorphentermine hydrochloride

Chlorphentermine hydrochloride

pharmaceutical raw materials
Chlorphentermine hydrochloride structure

Chlorphentermine hydrochloride 

structure
  • CAS No:

    151-06-4

  • Formula:

    C10H14ClN.ClH

  • Chemical Name:

    Chlorphentermine hydrochloride

  • Synonyms:

    Benzeneethanamine,4-chloro-α,α-dimethyl-,hydrochloride (1:1);Phenethylamine,p-chloro-α,α-dimethyl-,hydrochloride;Benzeneethanamine,4-chloro-α,α-dimethyl-,hydrochloride;S 62;S 62-2;WX 2426;Avicol;p-Chloro-α,α-dimethylphenethylamine hydrochloride;Chlorophentermine hydrochloride;Chlorphentermine hydrochloride;Lucofen;Lucofene;Pre-Sate;Presate hydrochloride;1-(p-Chlorophenyl)-2-methyl-2-aminopropane hydrochloride;Avicol (pharmaceutical);Chlorphenterminium chloride;p-Chlorphentermine hydrochloride;Dezopimon;Lukofen hydrochloride;Apsedon;Avipron;Clomina;Nilgana;4-Chloro-α,α-dimethylphenethylamine hydrochloride;W 2426;NSC 76098;[2-(4-Chlorophenyl)-1,1-dimethylethyl]amine hydrochloride;2-(4-Chloro-phenyl)-1,1-dimethyl-ethylamine hydrochloride;2-Amino-1-(p-chlorophenyl)-2-methylpropane hydrochloride;53529-57-0

  • Categories:

    Organic Chemistry  >  Amides

Description

Pre-Sate is a DEA Schedule III controlled substance. Substances in the DEA Schedule III have a potential for abuse less than substances in Schedules I or II and abuse may lead to moderate or low physical dependence or high psychological dependence.|Chlorphentermine Hydrochloride is the hydrochloride salt form of chlorphentermine, a chlorinated analogue of phentermine, a sympathomimetic amine with central nervous system (CNS) stimulating and anorexic activity. Chlorphentermine acts by facilitating the release of catecholamines, especially noradrenaline and dopamine, from nerve terminals in the brain and also inhibits their uptake. The increase in synaptic concentrations of these catecholamines causes behavioral changes including an increase in motor activity, mental alertness and excitement, causes euphoria, and suppresses appetite.|A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of DEXTROAMPHETAMINE. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)

Chlorphentermine hydrochloride Basic Attributes

220.137

219.058

205-782-9

RL11HOJ7DM

1645

76098

DTXSID1047815

C65324

Characteristics

26

234 °C

100-102 DEG C @ 2 MM HG

Oral-rat LD50: 150 mg/kg; Oral-Mouse LD50: 225 mg/kg

Flammable; burning produces toxic nitrogen oxides and hydrogen chloride fumes

Safety Information

Ventilated, low temperature and dry; stored separately from food materials in warehouse

STABLE IN LIGHT & AIR /CHLORPHENTERMINE HYDROCHLORIDE/

P201, P202, P264, P270, P281, P301+P310, P308+P313, P321, P330, P405, P501

H301

Toxicity

highly toxic

Drug Information

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

Avipron

Chlorphentermine|Pre-Sate, Lucofen, Apsedon, Desopimon|1645|Schedule III - Substances in the DEA Schedule III have a potential for abuse less than substances in Schedules I or II and abuse may lead to moderate or low physical dependence or high psychological dependence.|No

Chlorphentermine hydrochloride Use and Manufacturing

Uses

Chlorphentermine is an anorectic agent. Chlorphentermine is the 4-chloro derivative of the better known appetite suppressant Phentermine (P318830). Chlorphentermine is structurally related to amphetamine but is a relatively weak stimulant with little abuse potential.

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:220.14
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:219.0581549
Monoisotopic Mass:219.0581549
Topological Polar Surface Area:26
Heavy Atom Count:13
Complexity:137
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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