6-CHLORO-2,3-DIHYDRO-1H-INDENE-1-CARBOXYLIC ACID

Step 1 : To a solution of (3-methoxy-5-methylpyrazin-2-yl)methanamine hydrochloride (200 mg, 1.05 mmol) and 6-chloro-2, 3-dihydro-1H-indene-1 -carboxylic acid (206 mg, 1.05 mmol, 1 eq) in DCM (5 mL) was added HATU (479 mg, 1.26 mmol, 1.20 eq) and DIPEA (407 mg, 3.15 mmol, 550 mu, 3 eq). The mixture was stirred at 18C for 16 hours. The mixture washed with H2O (20 mL) and extracted with DCM (20 mL chi 3). The combined organic was dried over Na2S04 and concentrated under vacuum. 6-chloro-N-((3-methoxy-5-methylpyrazin-2-yl)methyl)-2, 3-dihydro-1H-indene-1-carboxamide (3 2 mg, 864 mumomicronIota, 82% yield) was obtained.Step 1: To a solution of (3-methoxy-5-methylpyrazin-2-yl)methanamine hydrochloride (200 mg, 1.05 mmol) and To a solution of (3-methoxy-5-methylpyrazin-2-yl)methanamine hydrochloride (200 mg, 1.05 mmol) and 6-chloro-2, 3-dihydro-1 H-indene-1-carboxylic acid (206 mg, 1.05 mmol, 1 eq) in DCM (5 mL) was added HATU (479 mg, 1.26 mmol, 1.20 eg) and DIPEA (407 mg, 3.15 mmol, 550 mu, 3 eg). The mixture was stirred at 18C for 16 hours. The mixture washed with H20 (20 mL) and extracted with DCM (20 mL * 3). The combined organic was dried over Na2S04 and concentrated under vacuum. 6-chloro-A/-((3-methoxy-5-methylpyrazin-2- yl)methyl)-2, 3-dihydro-1 H-indene-1 -carboxamide (312 mg, 864 pmol, 82% yield) was obtained.

Molecular Weight:196.63
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:196.0291072
Monoisotopic Mass:196.0291072
Topological Polar Surface Area:37.3
Heavy Atom Count:13
Complexity:217
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes