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Ceronapril

Ceronapril structure

CAS No:
111223-26-8
Formula:
C21H33N2O6P
Chemical Name:
Ceronapril
Synonyms:
L-Proline,1-[(2S)-6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-;L-Proline,1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-,(S)-;1-[(2S)-6-Amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline;SQ 29852;Ceranapril;Ceronapril;120122-26-1;124760-68-5
Categories:
Organic Chemistry > Phosphines

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Description

Ceronapril is a N-acyl-amino acid.

Ceronapril Basic Attributes

Molecular Weight：

440.474

Exact Mass：

440.47

UNII：

X3MM60SOVP

Characteristics

PSA：

130

XLogP3：

3.42270

Density：

1.265g/cm3

Melting Point：

190-195 °C

Boiling Point：

682.8ºC at 760 mmHg

Flash Point：

366.7ºC

Refractive Index：

1.559

Specific rotation：

D -47.5° (c = 1 in methanol)

Drug Information

MeSH：

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

1-(6-amino-2-((hydroxy(4-phenylbutyl)phosphinyl)oxy)-1-oxohexyl)proline

Ceronapril Use and Manufacturing

Antihypertensive.

Computed Properties

Molecular Weight:440.5
XLogP3:-0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:13
Exact Mass:440.20762377
Monoisotopic Mass:440.20762377
Topological Polar Surface Area:130
Heavy Atom Count:30
Complexity:596
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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