CI 992
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CI 992
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CAS No:
135704-06-2
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Formula:
C33H52N6O7S2
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Chemical Name:
CI 992
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Synonyms:
CI 992;CI-992;N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-L-alaninamide;(S)-3-(2-aminothiazol-4-yl)-2-(((2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl)amino)-N-((S)-2-(morpholine-4-sulfonamido)-3-phenylpropanoyl)propanamide;DTXSID10929117;2-[(1-Cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl)amino]-3-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-N-[N-(morpholine-4-sulfonyl)phenylalanyl]propanimidic acid;L-Alaninamide, N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-;N-(4-Morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-L-alaninamide
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CAS No:
CI 992 Use and Manufacturing
CI-992, is a novel potent orally active renin inhibitor, that has been proved to be effective on blood pressure on normotensive and hypertensive monkeys. It is also a derivative of Zankiren (Z148060).
Computed Properties
Molecular Weight:708.9
XLogP3:3.9
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:17
Exact Mass:708.33389037
Monoisotopic Mass:708.33389037
Topological Polar Surface Area:233
Heavy Atom Count:48
Complexity:1090
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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