2-Chloro-3-fluoro-4-pyridinamine
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2-Chloro-3-fluoro-4-pyridinamine
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CAS No:
1227577-03-8
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Formula:
C5H4ClFN2
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Chemical Name:
2-Chloro-3-fluoro-4-pyridinamine
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Synonyms:
4-Pyridinamine,2-chloro-3-fluoro-;2-Chloro-3-fluoro-4-pyridinamine;2-Chloro-3-fluoropyridin-4-ylamine
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CAS No:
Safety Information
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
2-Chloro-3-fluoro-4-pyridinamine Use and Manufacturing
TFA (5 mL) was added to a solution of (2- chloro-3-fluoropyridin-4-yl)carbamic acid fert-butyl ester (1.9 g, 7.7 mmol) in DCM (10 mL). The solution was stirred at ambient temperature for 5 hours and concentrated under reduced pressure. The resultant residue was dissolved in DCM and purified by column chromatography on a NHA suspension of 2-(5-chloro-2, 4-dimethoxyphenyl)-7-(piperazin- 1-yl)imidazo[ 1 , 2-a]pyridine 301 (500 mg, 1.3 mmol), To a solution of 2-(6-(difluoromethyl)pyridin-2-yl)-4-phenoxypyrrolo[2, 1- f][1, 2, 4]triazine (100 mg, 0.296 mmol) and To a solution of 2-(6-(difluoromethyl)pyridin-2-yl)-4-phenoxypyrrolo[2, 1- f][1, 2, 4]triazine (100 mg, 0.296 mmol) and To a 50 mL flask, was added 3.72.3. Step iii): 2-chloro-3-fluoro-5-iodine-4-aminopyridine To a solution of iodine (5.13 g, 20.2 mmol, 1.0 eq) in EtOH (50 mL) is added silver sulphate (6.30 g, 20.2 mmol, 1.0 eq) and
Computed Properties
Molecular Weight:146.55
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:146.0047040
Monoisotopic Mass:146.0047040
Topological Polar Surface Area:38.9
Heavy Atom Count:9
Complexity:101
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Chloro-3-fluoro-4-pyridinamine
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