7-chloro-6-nitrothieno[3,2-b]pyridine

A2.2: 6-Nitro-7-chlorothieno[3, 2-b]pyridine; A2.1 (9.5 g, 48.5 mmol) was suspended in phosphorus oxychloride (100 ml) and refluxed for 1 h (dissolution was apparent after 45 min). The solvent was removed under reduced pressure. Toluene (50 mL) was added to the residue and the volitiles were removed under reduced pressure. This procedure was repeated a second time to provide a dark colored semi-solid. Dichloromethane (400 mL) and saturated aqueous socium bicarbonate (400 mL) was added (Caution: gas evolution), and the layeres separated. The aqueous layer was washed with additional dichloromethane (100 mL). The combined organic layer was washed with water (200 mL) and dried over anhydrous sodium sulfate, decolorized by the addition of activated charcoal, and filtered through celite. The organic layer was concentrated to afford 9.7 g (93percent) of A2.2. M.S. 214 (M+H)POCl6-Nitrothieno[3, 2-b]pyridin-7-ol (3.3 g, 17 mmol) was suspended in phosphoryl chloride (30 mL, 400 mmol) and heated at reflux for 1 h (dissolution was apparent after 45 min) The solvent was removed. Toluene was added to the residue and the volatiles were removed in vacuo. Dichloromethane and sat. NaHCO

Molecular Weight:214.63
XLogP3:2.4
Hydrogen Bond Acceptor Count:4
Exact Mass:213.9603762
Monoisotopic Mass:213.9603762
Topological Polar Surface Area:87
Heavy Atom Count:13
Complexity:223
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes