2-Chloro-5-nitro-3-pyridinecarboxamide

Synthesis of the compound 22 The compound 21 (8.3 g, 0.04 mol) was added into thionyl chloride (80 mL) and refluxed for 3 h. The thionyl chloride was evaporated off, the acetone (240 mL) was added and stirred at 25°C, aqua ammoniae was added dropwise, and the reaction was run for 10 min before completed. The filtrate was concentrated to a quarter of the total volume, and the remaining concentrated solution was poured into 200g of broken ice, 4.5g of a yellow solid product was precipitated with a yield of 54.2percent. The melting point is 177.3-178.2 °C.

Molecular Weight:201.57
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:200.9941187
Monoisotopic Mass:200.9941187
Topological Polar Surface Area:102
Heavy Atom Count:13
Complexity:230
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes