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Carubicin hydrochloride

Carubicin hydrochloride structure

CAS No:
52794-97-5
Formula:
C26H27NO10.ClH
Chemical Name:
Carubicin hydrochloride
Synonyms:
5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-,hydrochloride (1:1),(8S,10S)-;5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-,hydrochloride,(8S-cis)-;5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-,hydrochloride,(8S,10S)-;Carminomycin hydrochloride;Carubicin hydrochloride;Karminomycin hydrochloride;NSC 275649;68594-07-0
Categories:
Biochemical Engineering > Saccharides

Description

Carubicin Hydrochloride is the hydrochloride salt of the anthracycline antineoplastic antibiotic carubicin. Carubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis.|A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.

Carubicin hydrochloride Basic Attributes

Molecular Weight：

550

Exact Mass：

549.140198

UNII：

4V3R166MB3

NCI Thesaurus Code：

C1582

Characteristics

PSA：

196.84000

XLogP3：

2.22820

Density：

1.63g/cm3

Boiling Point：

750.6ºC at 760mmHg

Flash Point：

407.7ºC

Toxicity：

LD50 in mice (mg/kg): 7.3 orally; 1.3 i.v.; 3.7 s.c. (Goldberg)

Specific rotation：

D20 +289°

Drug Information

MeSH：

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)|Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

MeSH Entry Terms：

Carminomicin

Carubicin hydrochloride Use and Manufacturing

Antineoplastic. .

Computed Properties

Molecular Weight:550.0
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:3
Exact Mass:549.1401738
Monoisotopic Mass:549.1401738
Topological Polar Surface Area:197
Heavy Atom Count:38
Complexity:944
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Guide of Carubicin hydrochloride

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

Carubicin hydrochloride

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