5-Chloro-1,3,4-thiadiazol-2-amine
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5-Chloro-1,3,4-thiadiazol-2-amine
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CAS No:
37566-40-8
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Formula:
C2H2ClN3S
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Chemical Name:
5-Chloro-1,3,4-thiadiazol-2-amine
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Synonyms:
1,3,4-Thiadiazol-2-amine,5-chloro-;5-Chloro-1,3,4-thiadiazol-2-amine;2-Amino-5-chloro-1,3,4-thiadiazole;NSC 231514
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CAS No:
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
5-Chloro-1,3,4-thiadiazol-2-amine Use and Manufacturing
Step 4: Step 4: A disposable tube was charged with (S)-l, 3-dihydrospiro[indene-2, 4'-piperidin]-l- amine (203 mg, 0.738 mmol, Intermediate I) triethylamine (148 mg, 1.47 mmol), 5-chloro- l, 3, 4-thiadiazol-2-amine (100 mg, 0.738 mmol, CAS 37566-40-8) and a stir bar. DMF (2 mL) was added and the solution was stirred at 80 C for 2 hr where the intermediate (S)-5-(l- amino- 1 , 3 -dihydrospiro[indene-2, 4'-piperidin]- 1 '-yl)- 1 , 3 , 4-thiadiazol-2-amine was formed. The reaction mixture was then partitioned between EtOAc and water. The layers were separated, and the aqueous layer was concentrated and dried under high vacuum.
Computed Properties
Molecular Weight:135.58
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:134.9657959
Monoisotopic Mass:134.9657959
Topological Polar Surface Area:80
Heavy Atom Count:7
Complexity:70
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
5-Chloro-1,3,4-thiadiazol-2-amine
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