2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine

(c) 47.7 g (0.82 mol) of potassium fluoride and 10.0 g (0.065 mol) of caesium fluoride are suspended in 300 ml of sulfolane and the suspension is heated to 140 C. 60 ml of sulfolane are distilled off by decreasing the pressure and subsequently 65.6 g (0.329 mol) of EXAMPLE 19 2-Chloro-3-fluoro-5-trifluoromethylpyridine A steel bomb was charged with 6-chloro-5-fluoronicotinic acid (5.4 g, 0.03 m), SF4 (32.4 g) and HF (5.6 ml). The mixture was heated at 120 for eight hours. After cooling to 25, the bomb was vented and the contents poured onto ice. The solution was neutralized with saturated Na2 CO3 solution and extracted with CH2 Cl2. The organic layer was dried over Na2 SO4, filtered and the solvent distilled off on a steam bath. The residue was distilled at 115 (760 mm) to yield 1.4 g (23% yield) of

Molecular Weight:199.53
XLogP3:2.8
Hydrogen Bond Acceptor Count:5
Exact Mass:198.9811894
Monoisotopic Mass:198.9811894
Topological Polar Surface Area:12.9
Heavy Atom Count:12
Complexity:160
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes