Elinogrel
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Elinogrel
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CAS No:
936500-94-6
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Formula:
C20H15ClFN5O5S2
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Chemical Name:
Elinogrel
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Synonyms:
2-Thiophenesulfonamide,5-chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-;5-Chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-2-thiophenesulfonamide;PRT 060128;Elinogrel;N-[4-(6-Fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)phenyl]-N′-[(5-chlorothiophen-2-yl)sulfonyl]urea;1-(5-Chlorothiophen-2-yl)sulfonyl-3-[4-[6-fluoro-7-(methylamino)-2,4-dioxo-1H-quinazolin-3-yl]phenyl]urea
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CAS No:
Description
Elinogrel (PRT060128) is a potent, direct acting, competitive, and reversible platelet P2Y12 antagonist (IC50=20 nM). It is orally and intravenously available and has potent antiplatelet effects[1].
A P2Y12 inhibitor and platelet aggregation inhibitor.
Drug Information
Investigated for use/treatment in cardiovascular disorders and myocardial infarction.
PRT060128 is a specific, reversible ADP receptor antagonist that binds to the P2Y12 receptor on platelets. PRT06128 prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, a key step in the coagulation cascade. PRT060128 likely has a similar mechanism of action to clopidogrel.
elinogrel
Computed Properties
Molecular Weight:523.9
XLogP3:3.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:523.0187168
Monoisotopic Mass:523.0187168
Topological Polar Surface Area:173
Heavy Atom Count:34
Complexity:914
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes