2-Chloro-N-(4-methoxyphenyl)-3-pyridinecarboxamide

A. 2-chloro-N-(4-Methoxyphenyl)pyridine-3-carboxamide. 2-Chloronicotinyl chloride hydrochloride (2.94 g, 16.5 mmol) was added in portions to a solution of pyridine (4.0 mL) and 4-anisidine (2.0 g, 16.2 mmol) in chloroform. After 0.5 h, the mixture was poured into EtOAc and 1 N NaOH. The organic layer was washed with 1 N NaOH (1*), water (1*), dried over potassium carbonate, and concentrated. The residue was purified by recrystallization (EtOAc:hexanes) yielding 2.56 g (60%) of the title compound. 1NMR, IR; FD-MS, m/e 262 (m); Analysis for C13H11ClN2O2: Calcd: C, 59.44; H, 4.22; N, 10.66; Found: C, 59.64; H, 4.45; N, 10.51.B. N-(4-Methoxyphenyl)-2-[1-(4-pyridyl)piperidin-4-yl-methyl]aminopyridine-3-carboxamide. A pressure tube (Aldrich) was charged with

Molecular Weight:262.69
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:262.0509053
Monoisotopic Mass:262.0509053
Topological Polar Surface Area:51.2
Heavy Atom Count:18
Complexity:280
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes