5-CHLORO-2-IODOPYRIDINE
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5-CHLORO-2-IODOPYRIDINE
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CAS No:
244221-57-6
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Formula:
C5H3ClIN
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Chemical Name:
5-CHLORO-2-IODOPYRIDINE
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Synonyms:
5-CHLORO-2-IODOPYRIDINE;2-IODO-5-CHLOROPYRIDINE
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CAS No:
Characteristics
12.9
2.2
Solid
2.1±0.1 g/cm3
85-87 °C(Solv: hexane (110-54-3))
237.3°C at 760 mmHg
97.3±21.8 °C
1.642
Slightly soluble in water.
0.03mmHg at 25°C
Safety Information
22
Xi,Xn
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
5-CHLORO-2-IODOPYRIDINE Use and Manufacturing
Preparation 1 5-Chloro-2-iodopyridineAcetyl chloride (11.05 ml_, 0.155 mol) was added to a solution of 2-bromo-5-chloropyridine (20.0 g, 0.103 mol) in acetonitrile (120 ml.) followed by sodium iodide (23.3 g, 0.155 mol) and the mixture was heated at reflux with a drying tube fitted for 3 hours. The reaction was cooled in an ice bath, carefully basified with saturated aqueous potassium carbonate then extracted with ethyl acetate (2 x 100 mL). The combined organic layers were washed with saturated aqueous sodium sulfite (200 mL), dried (MgSOPreparation 60; 5-Chloro-2-iodopyridine; Acetyl chloride (11.05 mL, 0.155 mol) was adde Xd to' a solution of 2-bromo-5-chloropyridine (20.0 g, 0.103 mol) in acetonitrile (120 mL) followed by sodium iodide (23.3 g, 0.155 mol) and the mixture was heated at reflux with a drying tube fitted for 3 hours. The reaction was cooled in an ice bath, carefully basified with saturated aqueous potassium carbonate then extracted with ethyl acetate (2 x 100 mL). The combined organic layers were washed with saturated aqueous sodium sulfite (200 mL), dried (MgSOa)
Computed Properties
Molecular Weight:239.44
XLogP3:2.2
Hydrogen Bond Acceptor Count:1
Exact Mass:238.89987
Monoisotopic Mass:238.89987
Topological Polar Surface Area:12.9
Heavy Atom Count:8
Complexity:78.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
