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2-Chloro-5-iodo-3-pyridinamine

2-Chloro-5-iodo-3-pyridinamine structure

CAS No:
426463-09-4
Formula:
C5H4ClIN2
Chemical Name:
2-Chloro-5-iodo-3-pyridinamine
Synonyms:
3-Pyridinamine,2-chloro-5-iodo-;2-Chloro-5-iodo-3-pyridinamine;2-Chloro-5-iodo-pyridin-3-ylamine;3-Amino-2-chloro-5-iodopyridine
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Pharmaceutical Intermediates > Bulk Drug Intermediates

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2-Chloro-5-iodo-3-pyridinamine Basic Attributes

Molecular Weight：

254.46

Exact Mass：

254.46

DSSTox ID：

DTXSID20363841

Characteristics

PSA：

38.9

XLogP3：

1.8

Density：

2.1±0.1 g/cm3

Melting Point：

128-133°C

Boiling Point：

352.5°C at 760 mmHg

Flash Point：

167.0±27.9 °C

Refractive Index：

1.708

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-41

safety instructions：

26-39

Marks：

Precautionary statement(s)：

P280-P305 + P351 + P338

Hazard Statements：

H302-H318

2-Chloro-5-iodo-3-pyridinamine Use and Manufacturing

5-Iodo-3-amino-2-chloropyridine 5-Iodo-3-amino-2-chloropyridine 5-Iodo-3-amino-2-chloropyridine 5-iodo-3-nitro-2-chloropyridine (230 mg, 0.809 mmol), ethanol (1 mL), water (6 drops), and concentrated HCl (0.020 mL) were stirred at room temperature for 10 min. Iron (500 mg, 8.95 mmol) was then added in small portions and the reaction round bottom flask was placed into a 100 C. oil bath for 20 min. The iron was removed by filtration, washed with ethanol, then the combined ethanol layers were concentrated under reduced pressure. The crude residue was purified by flash chromatography using 9:1 hexane: ethyl acetate to give 5-iodo-3-amino-2-chloropyridine (190 mg, 92%) as a colorless solid. mp 129 C.; 1H NMR (CDCl3) delta (ppm) 4.15 (br s, 2H), 7.34 (d, J=2.0 Hz, 1H), 7.96 (d, J=2.0 Hz, 1H); 13C NMR (CDCl3) delta (ppm) 91.41, 129.67, 136.31, 140.77, 143.90. Analytical Calculated for C5H4N2lCl: C, 23.60; H, 1.58; N, 11.01; Found: C, 23-66; H, 1.52; N, 10.98.

Computed Properties

Molecular Weight:254.45
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:253.91077
Monoisotopic Mass:253.91077
Topological Polar Surface Area:38.9
Heavy Atom Count:9
Complexity:101
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 426463-09-4

Grade: Pharmaceutical Grade

Content: 99%

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Guide of 2-Chloro-5-iodo-3-pyridinamine

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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2-Chloro-5-iodo-3-pyridinamine

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