Cilostamide
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Cilostamide
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CAS No:
68550-75-4
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Formula:
C20H26N2O3
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Chemical Name:
Cilostamide
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Synonyms:
Butanamide,N-cyclohexyl-4-[(1,2-dihydro-2-oxo-6-quinolinyl)oxy]-N-methyl-;N-Cyclohexyl-4-[(1,2-dihydro-2-oxo-6-quinolinyl)oxy]-N-methylbutanamide;Cilostamide;OPC 3689
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CAS No:
Description
Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.
N-cyclohexyl-N-methyl-4-[(2-oxo-1H-quinolin-6-yl)oxy]butanamide is a member of quinolines.
Characteristics
58.6
2.70
1.2±0.1 g/cm3
186-188 °C @ Solvent: Methanol, Water
594.3±50.0 °C at 760 mmHg
313.2±30.1 °C
1.586
0-6°C
Drug Information
Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases. (See all compounds classified as Phosphodiesterase Inhibitors.)|Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)
cilostamide
Computed Properties
Molecular Weight:342.4
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:342.19434270
Monoisotopic Mass:342.19434270
Topological Polar Surface Area:58.6
Heavy Atom Count:25
Complexity:499
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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