2-(2-Chloroethoxy)acetamide
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2-(2-Chloroethoxy)acetamide
structure -
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CAS No:
36961-64-5
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Formula:
C4H8ClNO2
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Chemical Name:
2-(2-Chloroethoxy)acetamide
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Synonyms:
Acetamide,2-(2-chloroethoxy)-;2-(2-Chloroethoxy)acetamide;(2-Chloroethoxy)acetamide
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CAS No:
Safety Information
P201, P202, P264, P270, P280, P281, P301+P312, P305+P351+P338, P308+P313, P330, P337+P313, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P280, P281, P301+P312, P305+P351+P338, P308+P313, P330, P337+P313, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-(2-Chloroethoxy)acetamide Use and Manufacturing
(b) I.5.1.1. 164 g (1.04 mol) of ethyl piperazinecarboxylate, 156.9 g (1.14 mol) of (2-chloroethoxy)acetamide, 241.7 g (2.28 mol) of sodium carbonate, 1 g of potassium iodide and 200 ml of toluene are introduced into a 2 1 three-necked round-bottomed flask fitted with a water-cooled condenser and a mechanical stirrer. The mixture is brought at the reflux temperature for 3 hours 30. The mixture is allowed to cool to 50 C., and 200 ml of isopropanol are added. The reaction mixture is filtered and the filtration residue is washed with 150 ml of isopropanol. The filtrate is concentrated on a rotary evaporator under reduced pressure. 272.2 g of crude product are obtained, which product is recrystallized from 500 ml of ethyl acetate. 219.2 g (81.6%) of ethyl (2-carbamoylmethoxyethyl)piperazine-1-carboxylate are obtained in the form of a white solid. NMR: delta: 1.24 (3H, t, 7.05 Hz); 2.46 (4H, m); 2.57 (2H, t, 5.2 Hz); 3.44 (4H, m); 3.62 (2H, t, 5.2 Hz); 3.95 (2H, s); 4.1 (2H, 9, 7.1 Hz); 5.72 (1H, bs); 7.34 (1H, bs). Mass spectrum: 260 (MH+).i) 8 gms of product of Example 5 or 6 were dissolved in 48 ml of toluene. 5.8 gms (0.04233 moles) of
Computed Properties
Molecular Weight:137.56
XLogP3:-0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:137.0243562
Monoisotopic Mass:137.0243562
Topological Polar Surface Area:52.3
Heavy Atom Count:8
Complexity:76.4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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