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Home > Encyclopedia > 1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one

1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one

1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one structure

1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one 

structure
  • CAS No:

    188116-07-6

  • Formula:

    C13H14ClN3O2

  • Chemical Name:

    1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one

  • Synonyms:

    1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one;Imepitoin;1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one;2H-Imidazol-2-one,1-(4-chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-;Imepitoin 1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one;AWD 131-138, >=98%;3-(4-chlorophenyl)-5-morpholin-4-yl-4H-imidazol-2-one

Description

AWD 131-138(Imepitoin) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.IC50 Value: Target: GABA receptorin vitro: AWD 131-138 dose-dependently stimulated GABA currents(Recombinant gamma-aminobutyric acid A (GABA(A)) receptors of the subunit compositions alpha1beta2gamma2, alpha1beta3gamma2, alpha2beta2gamma2, alpha3beta2gamma2 and alpha5beta2gamma2). At 10 microM AWD 131-138, this allosteric stimulation a

1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one Basic Attributes

279.724

279.077454

19V39682LI

DTXSID50172160

QN03AX90

Characteristics

45.1

1.2

1.42±0.1 g/cm3(Predicted)

264℃ (ethanol )

421.8±55.0 °C(Predicted)

208.9±31.5 °C

1.664

Safety Information

P201, P202, P281, P308+P313, P405, P501

H361F

|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|H361f: Suspected of damaging fertility [Warning Reproductive toxicity]

Drug Information

For the reduction of the frequency of generalised seizures due to idiopathic epilepsy in dogs for use after careful evaluation of alternative treatment options.

AWD 131-138

1-(4-chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one Use and Manufacturing

Methods of Manufacturing

Examples of compounds of the formula (I) include: 1-phenyl-4-morpholinoimidazolin-2-one, 1-(4-methoxy)-4-piperidinoimidazolin-2-one, 1-(4-chlorophenyl)-4-morpholinoimidazolin-2-one, 1-(4-chlorophenyl)-4-piperidinoimidazolin-2-one, 1-(4-chlorophenyl)-4-dimethylaminoimidazolin-2-one, 1-(3-chlorophenyl)-4-morpholinoimidazolin-2-one, 1-(4-chlorophenyl)-4-hexamethyleneiminoimidazolin-2-one, 1-(4-methylphenyl)-4-morpholinoimidazolin-2-one, 1-(4-chlorophenyl)-4-(cyclohexylmethylamino) imidazoline-2-one, ...A compound according to claim 1, the compound being 1-phenyl-4-morpholinoimidazolin-2-one, 1-(4-methoxy)-4-piperidinoimidazolin-2-one, 1-(4-chlorophenyl)-4-morpholinoimidazolin-2-one, 1-(4-chlorophenyl)-4-piperidinoimidazolin-2-one, 1-(4-chlorophenyl)-4-dimethylaminoimidazolin-2-one, 1-(3-chlorophenyl)-4-morpholinoimidazolin-2-one, 1-(4-chlorophenyl)-4-hexamethyleneiminoimidazolin-2-one, 1-(4-chlorophenyl)-4-methylpiperazino) imidazoline-2-one, 1-(4-methylphenyl)-4-morpholinoimidazolin-2-one, ...Examples of compounds of formula (I) include: 1-phenyl-4-morpholinoimidazolin-2-one, 1-(4-methoxy)-4-piperidinoimidazolin-2-one, 1-(4-chlorophenyl)-4-morpholinoimidazolin-2-one, 1-(4-chlorophenyl)-4-piperidinoimidazolin-2-one, 1-(4-chlorophenyl)-4-dimethylaminoimidazolin-2-one, The process of claim 1, wherein said compound is: ... 1-(4-chlorophenyl)-4-morpholinoimidazolin-2-one, 1-(4-chlorophenyl)-4-piperidinoimidazolin-2-one, 1-(4-chlorophenyl)-4-dimethylaminoimidazolin-2-one, 1-(3-chlorophenyl)-4-morpholinoimidazolin-2-one, 1-(4-chlorophenyl)-4-morpholinoimidazolin-2-one, 1-(4-chlorophenyl)-4-hexamethyleneiminoimidazolin-2-one, 1-(4-methylphenyl)-4-morpholinoimidazolin-2-one, 1-(4-chlorophenyl)-4-(cyclohexylmethylamino)imidazoline-s-one, ...

Veterinary drugs -> Pexion -> EMA Drug Category|Antiepileptics, Other antiepileptics -> Veterinary pharmacotherapeutic group|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:279.72
XLogP3:1.2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:279.0774544
Monoisotopic Mass:279.0774544
Topological Polar Surface Area:45.1
Heavy Atom Count:19
Complexity:374
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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