3-CHLORO-2-NITROBENZALDEHYDE

This example concerns the synthesis of Aldehyde 12: To a stirred solution of 81 (2.91 g, 13.5 mmol) and CHExample Al 3 a) Preparation of intermediate 28Pyridinium chlorochromate (67 g, 310 mmol) was added to a suspension of 3-chloro-2- nitrobenzylalcohol (25 g, 129 mmol), molecular sieves (40 g), and diatomaceous earth (40 g) in DCM (500 ml). The r.m. was stirred at r.t. for 2 h and then filtrated over silica (eluent: DCM). The product fractions were collected and the solvent was removed under reduced pressure. The residue was purified by chromatography over silica gel (eluent: DCM). The product fractions were collected and the solvent was evaporated. Yield: 22.5 g of intermediate 28 (94 percent).Example Al 3 a) Preparation of intermediate 28Pyridinium chlorochromate (67 g, 310 mmol) was added to a suspension of 3-chloro-2- nitrobenzylalcohol (25 g, 129 mmol), molecular sieves (40 g), and diatomaceous earth (40 g) in DCM (500 ml). The r.m. was stirred at r.t. for 2 h and then filtrated over silica (eluent: DCM). The product fractions were collected and the solvent was removed under reduced pressure. The residue was purified by chromatography over silica gel (eluent: DCM). The product fractions were collected and the solvent was evaporated. Yield: 22.5 g of intermediate 28 (94 %).

Molecular Weight:185.56
XLogP3:1.8
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:184.9879707
Monoisotopic Mass:184.9879707
Topological Polar Surface Area:62.9
Heavy Atom Count:12
Complexity:192
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes