2-Chloro-6-hydroxypurine
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2-Chloro-6-hydroxypurine
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CAS No:
13368-14-4
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Formula:
C5H3ClN4O
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Chemical Name:
2-Chloro-6-hydroxypurine
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Synonyms:
2-CHLOROHYPOXANTHINE;2-Chloro-6-hydroxypurine;2-Chloro-3,7-dihydro-6H-purin-6-one;2-chloro-7H-purin-6-ol;2-Chloro-1H-purin-6(7H)-one
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CAS No:
Characteristics
70.1
0.7
2.09±0.1 g/cm3(Predicted)
>300 °C
525.2°C at 760 mmHg
243.2±23.7 °C
1.808
0.00356mmHg at 25°C
2-Chloro-6-hydroxypurine Use and Manufacturing
2-(3-chlorobenzylamino)-6-hydroxypurine 4 mmol of 2-chloro-6-hydroxypurine were dissolved in 20 mL of butanol and then 5 mmol of 3-chlorobenzylamine and 6 mmol of triethylamine were added. The mixture was reacted at 90 C. for 4 hr. After cooling, the product was filter out and washed with water and butanol and crystallized from dimethyformamide or ethanol. HPLC: purity>91%. Yield 88%. Table 6 compound prepared by the method of example 8
