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7-chloroindolin-2-one

7-chloroindolin-2-one structure

CAS No:
25369-33-9
Formula:
C8H6ClNO
Chemical Name:
7-chloroindolin-2-one
Synonyms:
7-Chloro-2-oxindole98%;7-Chloro-2-Oxindole;7023 7-CHLOROINDOLIN-2-ONE;7-Chloro-1,3-dihydro-2H-indol-2-one, 7-Chloroindolin-2-one;2H-Indol-2-one, 7-chloro-1,3-dihydro-;7-Chloro-2-oxyindole;7-Chloro-2-oxindole 97%;7-Chloro-2-oxindole/7-chloro-1,3-dihydro-2H-indol-2-one
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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7-chloroindolin-2-one Basic Attributes

Molecular Weight：

167.59

Exact Mass：

167.59

EC Number：

625-279-1

HScode：

2933790090

Characteristics

PSA：

29.1

XLogP3：

1.4

Appearance：

WHITE TO TAN SOLID, POWDER, CRYSTALS,. CRYSTALLINE POWDER AND/OR CHUNKS

Density：

1.362±0.06 g/cm3(Predicted)

Melting Point：

221-225 °C

Boiling Point：

341.0±42.0 °C(Predicted)

Flash Point：

160.0±27.9 °C

Refractive Index：

1.602

Vapor Pressure：

8.27E-05mmHg at 25°C

PKA：

13.08±0.20(Predicted)

Critical Temperature & Pressure：

Sealed in dry,Room Temperature

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

Marks：

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

22-52/53

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

5-chlorooxindole

7-chloroindolin-2-one Use and Manufacturing

General procedure: Isatins (1a–j, 3.0 g), hydrazine hydrate (80percent, 13 mL) and water (13 mL) were added to a flask equipped with a thermometer with vigorous stirring. The reaction mixture was kept at 140 °C in an oil bath for 6 h before being cooled to r.t., when hydrochloric acid (2.0 mol L−1) was added to bring the pH to pH 2. The reaction mixture was stirred at r.t. for 12 h. Compounds 2a–j were obtained by filtering under vacuum and recrystallisation from absolute ethanol.General procedure: Weigh isatin (0.8g, 5.4mmol), the first of which was added 0.3g of 80% hydrazine hydrate (10ml) and heated to 100 C under reflux, was added portionwise remaining 0.5g, 2h addition was completed the temperature was raised to 110 C reflux was continued for 4h, cooled to room temperature, concentrated hydrochloric acid was added dropwise 36% was adjusted to pH = 3, stirring was continued at room temperature for 12h, the solid by suction filtration, washed with water and precipitation to give a brown solid (0.44g, 61%).(d) 7-chloro-oxindole, m.p. 218-220 C.

Computed Properties

Molecular Weight:167.59
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:167.0137915
Monoisotopic Mass:167.0137915
Topological Polar Surface Area:29.1
Heavy Atom Count:11
Complexity:183
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 7-chloroindolin-2-one

Hangzhou Royalchem Co.,LTD Contact Supplier

CN
2 YRS

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Trader Supplier of Pharmaceutical intermediates

7-Chloroindolin-2-one RC04201

Unit Price: $1 /KG EXW

CAS No.: 25369-33-9

Grade: Industrial Grade

Content: 99%

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