4-Chloro-7-hydroxyquinoline
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4-Chloro-7-hydroxyquinoline
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CAS No:
181950-57-2
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Formula:
C9H6ClNO
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Chemical Name:
4-Chloro-7-hydroxyquinoline
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Synonyms:
4-Chloro-7-hydroxyquinoline;7-Quinolinol,4-chloro-;4-chloroquinolin-7-ol
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CAS No:
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
4-Chloro-7-hydroxyquinoline Use and Manufacturing
4-chloro-7-methoxyquinoline 8b (3.86 g, 20 mmol), 40percent HBr (30 mL) and acetic anhydride (20 mL) were mixedHeating reflux, TLC tracking test, the reaction is completed, cooling the reaction solution to room temperature. Followed by the addition of lOOmL water to the reaction solution, 20percent NaOH solution to adjust the pH to 6.0, a large amount of solid precipitation, filtration, washing and drying to give an off-white solid (3.53 g, 98.6percent)After mixing 4-chloro-7-methoxyquinoline 8b (3.86 g, 20 mmol), 40percent HBr (30 mL) and acetic anhydrideHeated to reflux, TLC tracking test, the reaction was completed, the reaction was cooled to room temperature.Subsequently, 100 mL of water was added to the reaction mixture to dilute it. The 20percent NaOH solution was adjusted to pH 6.0. A large amount of solid was precipitated, filtered, washed with water and dried to give an off-white solid (3.53 g, 98.6percent).The protection of nitrogen, -70 °C under the condition of, to the 4 - chloro -7 - methoxy quinoline (0.95g, 4 . 9mmol) in dichloromethane (45 ml) solution slowly dropping BBrIn a 5-mL microwave tube dissolved 7-(benzyloxy)-4-chloroquinoline (0.54 g, 2.002 mmol) in 33percent HBr in AcOH (2 mL). Heated at 100 degrees in microwave for 10 min. Neutralized mixture with saturated NaHC0General procedure: A mixture of General procedure: A mixture of General procedure: A mixture of
Computed Properties
Molecular Weight:179.60
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:179.0137915
Monoisotopic Mass:179.0137915
Topological Polar Surface Area:33.1
Heavy Atom Count:12
Complexity:165
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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