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Mifobate

Mifobate structure

CAS No:
76541-72-5
Formula:
C11H17ClO7P2
Chemical Name:
Mifobate
Synonyms:
Phosphoric acid,(4-chlorophenyl)(dimethoxyphosphinyl)methyl dimethyl ester;Mifobate;SR 202
Categories:
Organic Chemistry > Phosphines

Description

Mifobate (SR-202) is a potent and specific PPARγ antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPARα, PPARβ, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects[1].

Phosphoric acid [(4-chlorophenyl)-dimethoxyphosphorylmethyl] dimethyl ester is a trialkyl phosphate.

Mifobate Basic Attributes

Molecular Weight：

358.65

Exact Mass：

358.65

DSSTox ID：

DTXSID6045741

HScode：

2931900090

Characteristics

PSA：

80.3

XLogP3：

4.24200

Appearance：

white crystalline

Density：

1.355g/cm3

Boiling Point：

436.6ºC at 760 mmHg

Flash Point：

350.8ºC

Refractive Index：

1.494

Water Solubility：

DMSO: 5 mg/mL

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

TB8817000

Drug Information

MeSH Entry Terms：

(4-chlorophenyl)(dimethoxyphosphinyl)methylphosphoric acid dimethyl ester

Mifobate Use and Manufacturing

Anti-atherosclerotic.

Computed Properties

Molecular Weight:358.65
XLogP3:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:358.0138046
Monoisotopic Mass:358.0138046
Topological Polar Surface Area:80.3
Heavy Atom Count:21
Complexity:395
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes