(4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE

Step 2: (4-Chloro-phenyl)-piperazin-l-yl-methanone (C)[00154] 4-(4-Chloro-benzoyl)-piperazine-l-carboxylic acid tert-butyl ester (26g) was dissolved in CHGeneral procedure: To a solution of 3a-3d (3.5 mmol) in CHGeneral procedure: For intermediate g, 0.02 mol aryl carboxylic acid was dissolved in 20 mL thionyl chloride, and the solution was stirred at reflux for 4 h. Then, 20 mL anhydrous chloroform was added into the solution, and thionyl chloride was removed in vacuo under reduced pressure to give intermediate e. Subsequently, intermediate e was dissolved in 10 mL chloroform and added dropwise into anthalazine dissolved in acetic acid. The solution was kept stirring at room temperature for 3 h, and then was alkalized in an ice bath with 20% sodium hydroxide till the pH value reached 9~10. Finally, the organic phase was extracted with chloroform (50 mL x 5), dried over anhydrous sodium sulfate overnight, and then evaporated under vacuum.Under the protection of anhydrous oxygen-free and inert gas, 0.0149 g (1.05×10-5 mol) {L1La[N(SiMe3)2]}2 was added to the reaction flask.Further, 0.0101 g (1.05 x 10-3 mol) of piperazine was added, and 1.31 mL of tetrahydrofuran was added.After stirring at room temperature for 0.5 hours. Then add 0.8661g (6.30×10-3 moles) of p-chlorobenzaldehyde, stir the reaction for 3 hours, the reaction is finished, pour the reaction solution into the eggplant-shaped bottle, add a small amount of ethyl acetate in the reaction bottle and wash it three times, still pour Into the eggplant-shaped bottle, add appropriate amount of silica gel, spin dry, and then load on the column of the prepared silica gel, and select the appropriate eluent (ethyl acetate: petroleum ether = 1:1) to pass the column to obtain the product. The yield was 94%.

Molecular Weight:224.68
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:224.0716407
Monoisotopic Mass:224.0716407
Topological Polar Surface Area:32.3
Heavy Atom Count:15
Complexity:221
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes