5-Chloropyridine-2-carboxylic acid
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5-Chloropyridine-2-carboxylic acid
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CAS No:
86873-60-1
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Formula:
C6H4ClNO2
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Chemical Name:
5-Chloropyridine-2-carboxylic acid
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Synonyms:
5-CHLORO-2-PYRIDINECARBOXYLIC ACID;5-CHLORO-2-PICOLINIC ACID;5-CHLOROPYRIDINE-2-CARBOXYLIC ACID;5-CHLOROPICOLINIC ACID;5-Chloropyridine-2-carboxylicacid98%;5-CHLORO-2-PYDRIDINECARBOXYLIC ACID;5-CHLOROPYRIDINE-2-CARBOXYLIC ACID 97%;5-CHLORO-2-PICOLINIC ACID (5-CHLORO-2-PYRIDINECARBOXYLIC ACID)
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CAS No:
Safety Information
IRRITANT
20/21/22-40-22
22-36
Xi,Xn
Harmful
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (82.61%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
5-Chloropyridine-2-carboxylic acid Use and Manufacturing
1000ml four-necked flask, fitted with a stirrer, thermometer, reflux condenser, is added 5-chloro-2-cyano-pyridine (27.7g, 0.2mo), 277 mg of the ethanol, and dissolved with stirring, an aqueous solution of 10percent NaOH was added 277ml, heated to 90 ~ 100 stirred at reflux for 1.5h, TLC TLC [discriminating the end of reaction conditions to expand (butanol - acetic acid - water = 5: 2: 2)], the reaction is complete, cooled to room temperature under stirring, the pH was adjusted to 2 with 2NHCl ~ 3, and concentrated under reduced pressure to a volume of 100ml, methanol was added to 200ml, cooled to 0 ~ 5 , filtered, the solid out, and the filtrate was concentrated to dryness under reduced pressure, the residue was added 450ml of dichloromethane and 50ml of methanol, stirred for 1h, filtered and the solid with the amount of 10percent methanol - methylene chloride mixture was washed, 60 ~ 65 vacuum oven vacuum drying 2h, as a white solid intermediate 525.5g, a yield of 81.4percent.Compound 17 (4.54 g, 23.6 mmol) was suspended in dried Et
Computed Properties
Molecular Weight:157.55
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:156.9930561
Monoisotopic Mass:156.9930561
Topological Polar Surface Area:50.2
Heavy Atom Count:10
Complexity:140
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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5-Chloropyridine-2-carboxylic acid
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