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CHS-828

CHS-828 structure

CAS No:
200484-11-3
Formula:
C19H22ClN5O
Chemical Name:
CHS-828
Synonyms:
GMX 1778;N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine;1-(6-(4-chlorophenoxy)hexyl)-2-cyano-3-(pyridin-4-yl)guanidine;GMX1778(CHS-828);2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine

Description

GMX1778(CHS-828) is a potent inhibitor of NAD+ biosynthesis enzyme NAMPT with IC50 <25 nM.IC50 value: < 25 nM [1]Target: NAMPT inhibitorin vitro: The phosphoribosyltransferase activity of recombinant NAMPT was sensitive to inhibition by GMX1778 (IC50 < 25 nM) whereas the adenyltransferase activity of recombinant NMNAT1 was not. The Kd of recombinant NAMPT for GMX1778 labeled with a fluorescent tag (GMX1778-Alexa Fluor) was 120 nM. Overexpression of wild-type NAMPT was able to maintain a

2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine is an aromatic ether.|CHS-828 has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.|Pyridyl Cyanoguanidine CHS 828 is a pyridyl cyanoguanidine that exhibits antitumor activity by an unknown mechanism. (NCI)

CHS-828 Basic Attributes

Molecular Weight：

371.87

Exact Mass：

371.151276

UNII：

8LAP87DNSZ

NCI Thesaurus Code：

C1852

Characteristics

PSA：

82.3

XLogP3：

4.3

Appearance：

white to beige

Density：

1.2±0.1 g/cm3

Flash Point：

272.4±32.3 °C

Refractive Index：

1.587

Water Solubility：

DMSO: soluble 20mg/mL, clear

Storage Conditions：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

25-36/37/38

safety instructions：

26-45

Marks：

Precautionary statement(s)：

P301 + P312 + P330-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 127 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

CHS 828

Computed Properties

Molecular Weight:371.9
XLogP3:4.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:11
Exact Mass:371.1512880
Monoisotopic Mass:371.1512880
Topological Polar Surface Area:82.3
Heavy Atom Count:26
Complexity:450
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 200484-11-3

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CAS No.: 200484-11-3

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Guide of CHS-828

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
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CHS-828

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